Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972209 | 0.88 | CA12 (0.51) | MAPTMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL7969844 | 0.87 | RAB9A (0.47) | MAPTMEN1KMT2AKDM4EPOLB | |
| SCHEMBL7970350 | 0.83 | MAPT (0.41) | MAPTMEN1KMT2AKDM4EPOLB | |
| SCHEMBL7972714 | 0.83 | MEN1 (0.50) | MAPTMEN1KMT2ASMN1; SMN2KDR | |
| SCHEMBL7973005 | 0.81 | KMT2A (0.49) | MAPTMEN1KMT2AKDM4EPOLB | |
| SCHEMBL7970519 | 0.80 | CNR1 (0.57) | MAPTMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL7970330 | 0.80 | RAB9A (0.64) | MAPTMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL7959073 | 0.79 | MAPT (0.57) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL7972214 | 0.79 | MAPT (0.44) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL7971235 | 0.79 | MAPT (0.45) | MAPTMEN1KMT2APOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |