Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.61 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972729 | 1.00 | ALOX5 (0.61) | ALOX5SLC9A1TSHRCACNA1FCACNA1D | |
| SCHEMBL7361743 | 0.80 | SLC9A1 (0.56) | SLC9A1TSHRCACNA1FCACNA1DCACNA1S | |
| SCHEMBL7973022 | 0.80 | ALOX5 (0.66) | ALOX5 | |
| SCHEMBL7969398 | 0.80 | ALOX5 (0.66) | ALOX5SLC9A1TP53 | |
| SCHEMBL7969393 | 0.80 | ALOX5 (0.66) | ALOX5SLC9A1TP53 | |
| SCHEMBL7973024 | 0.80 | ALOX5 (0.66) | ALOX5 | |
| SCHEMBL7969487 | 0.80 | ALOX5 (0.66) | ALOX5KDM1A | |
| SCHEMBL7970862 | 0.80 | ALOX5 (0.66) | ALOX5 | |
| SCHEMBL7970860 | 0.80 | ALOX5 (0.66) | ALOX5 | |
| SCHEMBL7969491 | 0.80 | ALOX5 (0.66) | ALOX5KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |