Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 13/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9192268 | 0.87 | KDM4E (0.38) | ALOX5ALOX12PTGS1PTGS2KDM4E | |
| SCHEMBL6846980 | 0.71 | GAA (0.39) | KDM4E | |
| SCHEMBL7975812 | 0.71 | SRD5A1 (0.37) | KDM4E | |
| SCHEMBL28534739 | 0.69 | DRD2 (0.42) | KDM4E | |
| SCHEMBL7975745 | 0.68 | ALOX5 (0.50) | ALOX5 | |
| SCHEMBL7975742 | 0.68 | ALOX5 (0.50) | ALOX5 | |
| SCHEMBL7959313 | 0.68 | CYP2C9 (0.47) | ALOX5KDM4E | |
| SCHEMBL20852815 | 0.66 | GAA (0.46) | — | |
| SCHEMBL20852796 | 0.66 | IDO1 (0.58) | — | |
| SCHEMBL24105190 | 0.66 | SLC18A3 (0.41) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |