Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28534739 | 0.75 | DRD2 (0.42) | SRD5A1ADRA1ASLC18A3SIGMAR1GAA | |
| SCHEMBL9518144 | 0.75 | TRPA1 (0.44) | SRD5A1ADRA1ASLC18A3SIGMAR1GAA | |
| SCHEMBL6169705 | 0.71 | GRIN2B (0.38) | SRD5A1ADRA1ASLC18A3SIGMAR1GAA | |
| SCHEMBL7973026 | 0.71 | ALOX5 (0.42) | KDM4E | |
| SCHEMBL21333362 | 0.70 | CES2 (0.33) | — | |
| SCHEMBL9192268 | 0.69 | KDM4E (0.38) | AKR1C3AKR1C1KDM4EHCAR2 | |
| SCHEMBL6846980 | 0.69 | GAA (0.39) | SLC18A3GAAMAPTKDM4E | |
| SCHEMBL25073357 | 0.68 | SLC18A3 (0.41) | SRD5A1ADRA1ASLC18A3SIGMAR1GAA | |
| SCHEMBL6740701 | 0.68 | SLC18A3 (0.41) | SRD5A1ADRA1ASLC18A3SIGMAR1GAA | |
| SCHEMBL17440328 | 0.68 | SLC18A3 (0.41) | SRD5A1ADRA1ASLC18A3SIGMAR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |
| EP-0559743-A1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE. | PFIZER HOSPITAL PROD (US) | 1993-09-15 | — | — | EP | disclosed |
| WO-1992009566-A1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER INC. (US) | 1992-06-11 | — | — | WO | disclosed |