Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.41 |
| ▸ | METAP1 | P53582 | 2/20 | 0.41 |
| ▸ | CBFB | Q13951 | 2/20 | 0.41 |
| ▸ | CNOT7 | Q9UIV1 | 3/20 | 0.41 |
| ▸ | PARN | O95453 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974054 | 0.89 | EGLN1 (0.44) | METAP2METAP1CBFBCNOT7PARN | |
| SCHEMBL7985494 | 0.88 | CNOT7 (0.52) | METAP2METAP1CNOT7PARNNPC1 | |
| SCHEMBL7992180 | 0.88 | SMN1; SMN2 (0.45) | METAP2METAP1CBFBCNOT7PARN | |
| SCHEMBL7991792 | 0.88 | ALDH1A1 (0.44) | METAP2METAP1CBFBCNOT7PARN | |
| SCHEMBL7985794 | 0.86 | PARN (0.46) | CNOT7PARNROCK2ROCK1GRIN1 | |
| SCHEMBL7985461 | 0.85 | TP53 (0.48) | ROCK2ROCK1NPY5RNPC1RAB9A | |
| SCHEMBL7991676 | 0.85 | ACP1 (0.43) | CNOT7PARNROCK2ROCK1GRIN1 | |
| SCHEMBL7988457 | 0.84 | PARN (0.42) | CNOT7PARNROCK2ROCK1GRIN1 | |
| SCHEMBL7985266 | 0.84 | CNOT7 (0.43) | CNOT7PARNROCK2ROCK1GRIN1 | |
| SCHEMBL7988644 | 0.84 | GRIN1 (0.42) | CNOT7PARNROCK2ROCK1GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |