Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | PRKCB | P05771 | 1/20 | 0.43 |
| ▸ | GRK2 | P25098 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
| ▸ | GRK6 | P43250 | 1/20 | 0.43 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.43 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.43 |
| ▸ | GRK7 | Q8WTQ7 | 1/20 | 0.43 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991792 | 0.87 | ALDH1A1 (0.44) | NPC1RAB9ALMNANPY5R | |
| SCHEMBL7974021 | 0.87 | TP53 (0.51) | TP53RXFP1GAAROCK2ROCK1 | |
| SCHEMBL7985852 | 0.86 | TP53 (0.52) | TP53RXFP1GAAROCK2ROCK1 | |
| SCHEMBL7985494 | 0.86 | CNOT7 (0.52) | RXFP1GAANPC1RAB9ALMNA | |
| SCHEMBL7989314 | 0.85 | ROCK2 (0.55) | TP53RXFP1GAAROCK2ROCK1 | |
| SCHEMBL7974009 | 0.85 | METAP2 (0.41) | NPC1RAB9AROCK2ROCK1NPY5R | |
| SCHEMBL7992180 | 0.85 | SMN1; SMN2 (0.45) | NPC1RAB9AYTHDC1P2RX7 | |
| SCHEMBL7985453 | 0.85 | GAA (0.52) | TP53RXFP1GAANPC1RAB9A | |
| SCHEMBL7985875 | 0.84 | TP53 (0.48) | TP53RXFP1GAAROCK2ROCK1 | |
| SCHEMBL7974586 | 0.83 | GAA (0.52) | TP53RXFP1GAAMAPTP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |