SCHEMBL7974044

SCHEMBL7974044

BrCc1ccc2c(c1)Cc1ccccc1-2

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.59
ALDH1A1 P00352 2/20 0.59
ATM Q13315 1/20 0.59
NPSR1 Q6W5P4 1/20 0.59
RAB9A P51151 4/20 0.54
SMN1; SMN2 Q16637 3/20 0.54
NPC1 O15118 3/20 0.54
TP53 P04637 1/20 0.54
MAPK1 P28482 1/20 0.54
KDM4E B2RXH2 1/20 0.53
LMNA P02545 1/20 0.53
MAPT P10636 1/20 0.53
HPGD P15428 1/20 0.53
CYP17A1 P05093 1/20 0.51
SRD5A2 P31213 1/20 0.47
GPR84 Q9NQS5 1/20 0.47
HTT P42858 1/20 0.47
CYP1A2 P05177 3/20 0.46
CYP3A4 P08684 2/20 0.46
CYP2D6 P10635 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29780668 1.00 TSHR (0.59) TSHRALDH1A1ATMNPSR1RAB9A
SCHEMBL7540168 0.90 TSHR (0.46) TSHRALDH1A1ATMNPSR1RAB9A
SCHEMBL3453144 0.85 TSHR (0.53) TSHRALDH1A1ATMNPSR1RAB9A
SCHEMBL598903 0.84 TSHR (0.58) TSHRALDH1A1ATMNPSR1RAB9A
SCHEMBL7195015 0.84 GPR84 (0.60) TSHRALDH1A1ATMNPSR1RAB9A
SCHEMBL8718934 0.82 ALDH1A1 (0.43) TSHRALDH1A1ATMNPSR1RAB9A
SCHEMBL19543695 0.81 TSHR (0.64) TSHRALDH1A1ATMNPSR1RAB9A
SCHEMBL2965416 0.81 TSHR (0.55) TSHRALDH1A1ATMNPSR1RAB9A
SCHEMBL18536625 0.81 TSHR (0.55) TSHRALDH1A1ATMNPSR1RAB9A
SCHEMBL5357579 0.81 ALDH1A1 (0.59) TSHRALDH1A1ATMNPSR1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110691806-B Copolymer and organic light emitting device including the same 株式会社LG化学 2022-07-05 CN disclosed
US-11309494-B2 Copolymer and organic light emitting device comprising same LG CHEM, LTD. 2022-04-19 US disclosed
US-20200185611-A1 Copolymer And Organic Light Emitting Device Comprising Same LG CHEM, LTD. (KR) 2020-06-11 US disclosed
CN-110691806-A Copolymer and organic light emitting device including the same 株式会社LG化学 2020-01-14 CN disclosed
WO-2001077095-A2 DERIVATIVES OF ALPHA-MERCAPTOACETAMIDE NOVARTIS AG (CH) 2001-10-18 WO disclosed
EP-0049628-B1 NONAPEPTIDE AND DECAPEPTIDE ANALOGS OF LHRH, USEFUL AS LHRH ANTAGONISTS, METHODS OF MAKING THEM, AND THEIR PHARMACEUTICAL USES SYNTEX (U.S.A.) INC. (US) 1985-07-03 EP disclosed
EP-0021234-B1 NONAPEPTIDE AND DECAPEPTIDE DERIVATIVES OF LUTEINIZING HORMONE RELEASING HORMONE, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SYNTEX (U.S.A.) INC. (US) 1984-08-22 EP disclosed
US-4419347-A Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists SYNTEX (U.S.A.) INC. (US) 1983-12-06 US disclosed
US-4341767-A Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists SYNTEX INC. (US) 1982-07-27 US disclosed
EP-0049628-A2 Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists, methods of making them, and their pharmaceutical uses SYNTEX (U.S.A.) INC. (US) 1982-04-14 EP disclosed
EP-0021234-A1 Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone, their preparation and pharmaceutical compositions containing them SYNTEX (U.S.A.) INC. (US) 1981-01-07 EP disclosed
US-4234571-A CONTRACEPTIVES, ANTIFERTILITY AGENTS SYNTEX (U.S.A.) INC. (US) 1980-11-18 US disclosed