SCHEMBL8718934

SCHEMBL8718934

BrCc1ccc2c(c1)Cc1cc(CBr)ccc1-2.c1ccc(P(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.43
TSHR P16473 3/20 0.43
NPSR1 Q6W5P4 2/20 0.43
ATM Q13315 1/20 0.43
CYP3A4 P08684 2/20 0.40
TDP1 Q9NUW8 1/20 0.40
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
TP53 P04637 1/20 0.39
MAPK1 P28482 1/20 0.39
CYP17A1 P05093 1/20 0.38
TRPA1 O75762 1/20 0.38
KDM4E B2RXH2 2/20 0.36
LMNA P02545 2/20 0.36
MAPT P10636 1/20 0.36
HPGD P15428 1/20 0.36
SRD5A2 P31213 1/20 0.36
ESR1 P03372 2/20 0.35
ESR2 Q92731 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7540168 0.84 TSHR (0.46) ALDH1A1TSHRNPSR1ATMCYP3A4
SCHEMBL7974044 0.82 TSHR (0.59) ALDH1A1TSHRNPSR1ATMCYP3A4
SCHEMBL29780668 0.82 TSHR (0.59) ALDH1A1TSHRNPSR1ATMCYP3A4
SCHEMBL30705746 0.76 TRPA1 (0.59) ALDH1A1TSHRCYP3A4TDP1TRPA1
SCHEMBL19678032 0.74 ALDH1A1 (0.52) ALDH1A1TSHRCYP3A4TDP1TRPA1
SCHEMBL1138241 0.74 CYP1A2 (0.47) ALDH1A1TSHRCYP3A4TDP1TRPA1
Benzyl Bromide SCHEMBL1043932 0.73 TSHR (0.70) ALDH1A1TSHRCYP3A4TDP1SMN1; SMN2
Bromide SCHEMBL160231 0.73 ALDH1A1 (0.50) ALDH1A1TSHRCYP3A4TDP1TRPA1
SCHEMBL4962307 0.72 SIGMAR1 (0.45) ALDH1A1TSHRCYP3A4TDP1NPC1
SCHEMBL7947551 0.72 RXRA (0.46) ALDH1A1TSHRTRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5807974-A POLYARYLENEVINYLENE RESIN KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 1998-09-15 US disclosed