Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.31 |
| ▸ | MMP9 | P14780 | 4/20 | 0.31 |
| ▸ | MMP3 | P08254 | 3/20 | 0.31 |
| ▸ | MMP1 | P03956 | 3/20 | 0.31 |
| ▸ | MMP13 | P45452 | 3/20 | 0.31 |
| ▸ | MMP7 | P09237 | 1/20 | 0.31 |
| ▸ | MMP14 | P50281 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7566608 | 0.67 | HPGD (0.36) | MMP2MMP9MMP3MMP1MMP13 | |
| SCHEMBL7077739 | 0.66 | CYP1A2 (0.34) | MMP2MMP9MMP3MMP13 | |
| SCHEMBL7221727 | 0.65 | MMP2 (0.37) | MMP2MMP9MMP3MMP1MMP13 | |
| SCHEMBL7454548 | 0.63 | MMP1 (0.32) | MMP2MMP9MMP3MMP1MMP13 | |
| SCHEMBL4818302 | 0.62 | PLA2G7 (0.43) | MMP2MMP9MMP3MMP1MMP13 | |
| SCHEMBL4822556 | 0.62 | PLA2G7 (0.43) | MMP2MMP9MMP3MMP1MMP13 | |
| SCHEMBL4818312 | 0.62 | PLA2G7 (0.43) | MMP2MMP9MMP3MMP1MMP13 | |
| SCHEMBL7078773 | 0.62 | — | — | |
| SCHEMBL6952582 | 0.62 | MMP2 (0.38) | MMP2MMP9MMP3MMP1MMP13 | |
| SCHEMBL6947897 | 0.61 | CPB2 (0.48) | MMP2MMP9MMP3MMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187924-B1 | INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TUMOR NECROSIS FACTOR-ALPHA-MEDIATED DISEASES | DARWIN DISCOVERY, LTD. (GB) | 2001-02-13 | — | — | US | disclosed |