Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.34 |
| ▸ | MMP2 | P08253 | 4/20 | 0.33 |
| ▸ | MMP9 | P14780 | 4/20 | 0.33 |
| ▸ | MMP3 | P08254 | 3/20 | 0.33 |
| ▸ | MMP1 | P03956 | 3/20 | 0.33 |
| ▸ | MMP13 | P45452 | 3/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7977189 | 0.85 | PLA2G7 (0.39) | PLA2G7NR1H2NR1H3MMP2MMP9 | |
| SCHEMBL8019774 | 0.69 | PLA2G7 (0.46) | PLA2G7NR1H2NR1H3MMP2MMP9 | |
| SCHEMBL6945464 | 0.69 | PLA2G7 (0.49) | PLA2G7NR1H2NR1H3MMP2MMP9 | |
| SCHEMBL7603860 | 0.68 | PLA2G7 (0.40) | PLA2G7NR1H2NR1H3MMP2MMP9 | |
| SCHEMBL7221727 | 0.68 | MMP2 (0.37) | PLA2G7NR1H2NR1H3MMP2MMP9 | |
| SCHEMBL7448180 | 0.67 | PLA2G7 (0.42) | PLA2G7NR1H2NR1H3MMP2MMP9 | |
| SCHEMBL7968322 | 0.67 | PLA2G7 (0.47) | PLA2G7NR1H2NR1H3 | |
| SCHEMBL7028144 | 0.66 | MMP2 (0.44) | PLA2G7NR1H2NR1H3MMP2MMP9 | |
| SCHEMBL4756856 | 0.66 | KMT2A (0.56) | PLA2G7MMP2MMP9MMP3MMP1 | |
| SCHEMBL11272468 | 0.66 | MGLL (0.47) | PLA2G7NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187924-B1 | INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TUMOR NECROSIS FACTOR-ALPHA-MEDIATED DISEASES | DARWIN DISCOVERY, LTD. (GB) | 2001-02-13 | — | — | US | disclosed |