Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | PARN | O95453 | 1/20 | 0.43 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984975 | 0.94 | CXCR2 (0.53) | CXCR2PARNCNOT7GRIN1GRIN2B | |
| SCHEMBL7987953 | 0.89 | PDE2A (0.46) | CXCR2PARNCNOT7SCN2AADORA3 | |
| SCHEMBL7985794 | 0.86 | PARN (0.46) | PARNCNOT7GRIN1GRIN2BROCK2 | |
| SCHEMBL7975271 | 0.86 | CNOT7 (0.56) | CXCR2RXFP1PARNCNOT7ADORA2B | |
| SCHEMBL7988017 | 0.84 | KDM4E (0.43) | CXCR2MAPTGRIN1GRIN2B | |
| SCHEMBL7988669 | 0.84 | PARN (0.48) | CXCR2PARNCNOT7 | |
| SCHEMBL7974270 | 0.84 | ALDH1A1 (0.46) | MAPTLMNATP53PARNCNOT7 | |
| SCHEMBL7974069 | 0.84 | ALDH1A1 (0.48) | CXCR2MAPTLMNATP53RXFP1 | |
| SCHEMBL7987255 | 0.82 | PARN (0.48) | PARNCNOT7GRIN1GRIN2B | |
| SCHEMBL7974021 | 0.82 | TP53 (0.51) | MAPTLMNATP53RXFP1PARN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |