Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984971 | 0.94 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2KMT2AHPGDCXCR2 | |
| SCHEMBL7987948 | 0.89 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2KMT2AHPGDCXCR2 | |
| SCHEMBL7985787 | 0.86 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2KMT2AHPGDMKNK1 | |
| SCHEMBL7975265 | 0.86 | SMN1; SMN2 (0.61) | ALDH1A1SMN1; SMN2KMT2AHPGDRXFP1 | |
| SCHEMBL7988015 | 0.84 | HPGD (0.43) | ALDH1A1SMN1; SMN2KMT2AHPGDMAPT | |
| SCHEMBL7988662 | 0.84 | SMN1; SMN2 (0.53) | ALDH1A1SMN1; SMN2KMT2AHPGDMKNK1 | |
| SCHEMBL7974266 | 0.84 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2KMT2AHPGDMAPT | |
| SCHEMBL7974074 | 0.84 | CXCR2 (0.45) | MAPTLMNATP53RXFP1MKNK1 | |
| SCHEMBL7987251 | 0.82 | SMN1; SMN2 (0.53) | ALDH1A1SMN1; SMN2KMT2AHPGD | |
| SCHEMBL7974016 | 0.82 | GAA (0.56) | ALDH1A1SMN1; SMN2KMT2AHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |