Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | PRKCG | P05129 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988883 | 0.85 | CYP11B1 (0.46) | TNFSMN1; SMN2LMNAMAPTTP53 | |
| SCHEMBL7987434 | 0.83 | CYP11B1 (0.42) | SMN1; SMN2LMNAMAPTHTTTLR7 | |
| SCHEMBL7984378 | 0.81 | CYP11B1 (0.42) | SMN1; SMN2TLR7ALDH1A1GAA | |
| SCHEMBL7974260 | 0.81 | CYP11B1 (0.47) | SMN1; SMN2LMNAPOLBMAPTHTT | |
| SCHEMBL7987960 | 0.79 | CYP11B1 (0.32) | LMNAPOLBHTTTLR7 | |
| SCHEMBL7984440 | 0.77 | PDE4A (0.40) | LMNAPOLBTP53MAPK1PDE4B | |
| SCHEMBL7988129 | 0.76 | MET (0.44) | SMN1; SMN2LMNAPOLBTLR7TSHR | |
| SCHEMBL7975252 | 0.76 | HPGD (0.45) | TNFSMN1; SMN2POLBTSHRALDH1A1 | |
| SCHEMBL7974269 | 0.74 | TNF (0.44) | TNFSMN1; SMN2LMNAPOLBMAPT | |
| SCHEMBL7984526 | 0.74 | MET (0.46) | SMN1; SMN2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |