Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7989377 | 0.91 | LMNA (0.44) | CYP11B1CYP11B2LMNASMN1; SMN2HTT | |
| SCHEMBL7988129 | 0.91 | MET (0.44) | LMNASMN1; SMN2METHPGDKMT2A | |
| SCHEMBL7984526 | 0.88 | MET (0.46) | CYP11B1CYP11B2SMN1; SMN2HTTMET | |
| SCHEMBL7975252 | 0.88 | HPGD (0.45) | CYP11B1CYP11B2SMN1; SMN2HPGDMEN1 | |
| SCHEMBL7984378 | 0.88 | CYP11B1 (0.42) | CYP11B1CYP11B2SMN1; SMN2METHPGD | |
| SCHEMBL8059823 | 0.86 | MEN1 (0.45) | SMN1; SMN2TP53MAPTHPGDMEN1 | |
| SCHEMBL7973934 | 0.86 | CYP11B1 (0.45) | CYP11B1CYP11B2SMN1; SMN2METHPGD | |
| SCHEMBL7975137 | 0.86 | LMNA (0.42) | CYP11B1CYP11B2LMNASMN1; SMN2HTT | |
| SCHEMBL7984468 | 0.86 | ABCC8 (0.46) | CYP11B1CYP11B2LMNASMN1; SMN2MET | |
| SCHEMBL7988035 | 0.86 | SMN1; SMN2 (0.39) | CYP11B1CYP11B2LMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |