Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 8/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974714 | 0.84 | MAPT (0.35) | KDM4EMAPK1HIF1A | |
| SCHEMBL7972860 | 0.81 | KDM4E (0.46) | KDM4EMAPK1HIF1APAOXMTNR1A | |
| SCHEMBL7977162 | 0.77 | NAAA (0.40) | — | |
| SCHEMBL8291459 | 0.73 | DRD3 (0.58) | KDM4EMAPK1HIF1AMTNR1ANAMPT | |
| SCHEMBL23471393 | 0.72 | KDM4E (0.64) | KDM4EMAPK1HIF1APAOXNAMPT | |
| SCHEMBL23471410 | 0.70 | KDM4E (0.60) | KDM4EMAPK1HIF1APAOXNAMPT | |
| SCHEMBL24115530 | 0.68 | SIGMAR1 (0.59) | KDM4EMAPK1HIF1APAOXADRA1A | |
| SCHEMBL19731592 | 0.66 | SIGMAR1 (0.56) | KDM4EMAPK1HIF1APAOXADRA1A | |
| SCHEMBL14739904 | 0.66 | KDM4E (1.00) | KDM4EMAPK1HIF1APAOXNAMPT | |
| SCHEMBL1900654 | 0.66 | KDM4E (1.00) | KDM4EMAPK1HIF1APAOXNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6326369-B1 | ALZHEIMER'S DISEASE | TAKEDA CHEMICALS INDUSTRIES, LTD. (JP) | 2001-12-04 | — | — | US | disclosed |
| EP-0968164-A1 | BICYCLIC QUINONE COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998033758-A1 | BICYCLIC QUINONE COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-08-06 | — | — | WO | disclosed |