Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 2/20 | 0.58 |
| ▸ | NAMPT | P43490 | 5/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 9/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8292402 | 0.89 | MTNR1A (0.62) | DRD3NAMPTMTNR1AMTNR1BL3MBTL1 | |
| SCHEMBL7281450 | 0.78 | MTNR1A (0.68) | DRD3MTNR1AMTNR1B | |
| SCHEMBL8300330 | 0.76 | TBXA2R (0.43) | DRD3NAMPTMTNR1AMTNR1B | |
| SCHEMBL23471410 | 0.76 | KDM4E (0.60) | DRD3NAMPTL3MBTL1KDM4EMAPK1 | |
| SCHEMBL23471393 | 0.74 | KDM4E (0.64) | NAMPTKDM4EMAPK1HIF1A | |
| SCHEMBL27817497 | 0.73 | IDO1 (0.46) | MTNR1AMTNR1BKDM4E | |
| SCHEMBL25131080 | 0.73 | NAMPT (0.71) | NAMPT | |
| SCHEMBL7974358 | 0.73 | KDM4E (0.43) | DRD3NAMPTMTNR1AMTNR1BL3MBTL1 | |
| SCHEMBL7263051 | 0.72 | IDO1 (0.48) | DRD3 | |
| SCHEMBL7972860 | 0.72 | KDM4E (0.46) | DRD3NAMPTMTNR1AMTNR1BL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661273-B1 | Indane derivatives and processes for preparing the same | TANABE SEIYAKU CO (JP) | 1999-05-19 | — | — | EP | disclosed |
| US-5686452-A | PROTECTING FROM ENDOTOXIN SHOCK; TREATMENT OF NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1997-11-11 | — | — | US | disclosed |
| EP-0661273-A1 | Indane derivative and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |