Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.37 |
| ▸ | QPCT | Q16769 | 2/20 | 0.36 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988734 | 0.91 | MET (0.44) | METCYP11B1CYP11B2MAPK14GRM2 | |
| SCHEMBL7985299 | 0.90 | CDK9 (0.39) | CYP11B1CYP11B2MAPK14ADORA2AKDM4E | |
| SCHEMBL7985613 | 0.90 | MET (0.46) | METCYP11B1CYP11B2ADORA2AHSD17B13 | |
| SCHEMBL7984659 | 0.90 | ALDH1A1 (0.44) | CYP11B1CYP11B2ADORA2AKDM4EMEN1 | |
| SCHEMBL7988781 | 0.89 | MET (0.43) | METCYP11B1CYP11B2LMNAHSD17B13 | |
| SCHEMBL7984423 | 0.89 | SMN1; SMN2 (0.38) | CYP11B1CYP11B2ADORA2AKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL7987662 | 0.89 | ALDH1A1 (0.43) | CYP11B1CYP11B2ADORA2AKDM4EMEN1 | |
| SCHEMBL7986521 | 0.88 | CYP11B1 (0.47) | METCYP11B1CYP11B2ADORA2AKDM4E | |
| SCHEMBL7991400 | 0.86 | NR1H4 (0.43) | ADORA2AKDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL7984281 | 0.86 | MET (0.52) | METCYP11B1CYP11B2MAPK14QPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |