Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 4/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | BRD2 | P25440 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975381 | 0.90 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9ANPC1HPGDNFKB1 | |
| SCHEMBL7964033 | 0.83 | EGLN3 (0.47) | SMN1; SMN2RAB9ANPC1HPGDNFKB1 | |
| SCHEMBL7964032 | 0.82 | NPC1 (0.60) | SMN1; SMN2RAB9ANPC1HPGDNFKB1 | |
| SCHEMBL7964039 | 0.81 | RAB9A (0.54) | SMN1; SMN2RAB9ANPC1HPGDNFKB1 | |
| SCHEMBL7964004 | 0.81 | NPC1 (0.55) | SMN1; SMN2RAB9ANPC1HPGDNFKB1 | |
| SCHEMBL7964015 | 0.81 | EPHX2 (0.64) | SMN1; SMN2RAB9ANPC1HPGDNFKB1 | |
| SCHEMBL7964029 | 0.80 | RAB9A (0.70) | SMN1; SMN2RAB9ANPC1HPGDNFKB1 | |
| SCHEMBL7980296 | 0.79 | SMN1; SMN2 (0.57) | SMN1; SMN2RAB9ANPC1HPGDNFKB1 | |
| SCHEMBL7977579 | 0.77 | RAB9A (0.66) | SMN1; SMN2RAB9ANPC1HPGDNFKB1 | |
| SCHEMBL7975333 | 0.76 | PDCD1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |