Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.35 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL460391 | 1.00 | TSHR (0.47) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL9288862 | 0.88 | TSHR (0.41) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Acrylic Acid SCHEMBL936884 | 0.86 | LMNA (0.56) | TSHRTP53LMNACA1CA2 | |
| Bicarbonate SCHEMBL1206563 | 0.86 | CA1 (0.41) | TSHRTP53LMNACA1CA2 | |
| Oxalic Acid SCHEMBL28528613 | 0.83 | CA1 (0.39) | TSHRTP53LMNACA1CA2 | |
| Hydrogen Peroxide SCHEMBL11812678 | 0.83 | — | — | |
| Carbamic Acid SCHEMBL28274511 | 0.81 | MAPT (0.42) | TSHRTP53LMNACA1CA2 | |
| Acetic Acid SCHEMBL27627871 | 0.81 | FFAR3 (0.39) | TSHRTP53LMNACA1CA2 | |
| Acetic Acid SCHEMBL131569 | 0.81 | FFAR3 (0.39) | TSHRTP53LMNACA1CA2 | |
| SCHEMBL540637 | 0.81 | MEN1 (0.34) | HCAR2MAPTCACNA1BAPBA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118359899-A | Thermoplastic polyether ester elastomer composition with low melt index and high weldability and preparation method thereof | 会通新材料(上海)有限公司 | 2024-07-19 | — | — | CN | disclosed |
| US-6287552-B1 | SPEADING ON SKIN; DRYING | L'OREAL (FR) | 2001-09-11 | — | — | US | disclosed |
| US-6284233-B1 | Antiwrinkle composition comprising a combination of tightening polymers of synthetic and/or natural origin and of dendritic polyesters | L'OREAL (FR) | 2001-09-04 | — | — | US | disclosed |
| CN-1249169-A | Local beauty or skin composition contg. dendritic polyester | OREAL (FR) | 2000-04-05 | — | — | CN | disclosed |
| CN-1249170-A | Wrinkle-proof composition contg. synthetic and/or natural tightening polymer and dendritic polyester mixture | OREAL (FR) | 2000-04-05 | — | — | CN | disclosed |
| JP-2000086895-A | PRODUCTION OF ADDITION REACTION TYPE SILICONE RUBBER | SANYO ELECTRIC CO LTD | 2000-03-28 | — | — | JP | disclosed |
| EP-0779908-B1 | RADIATION CURABLE RESINS COMPRISING HYPERBRANCHED POLYESTERS | NESTE CHEMICALS OY (FI) | 1999-12-08 | — | — | EP | disclosed |
| US-5834118-A | Radiation curable resins comprising hyperbranched polyesters | NESTE OY OF KEILANIEMI (FI) | 1998-11-10 | — | — | US | disclosed |
| EP-0779908-A1 | RADIATION CURABLE RESINS COMPRISING HYPERBRANCHED POLYESTERS | NESTE OY (FI) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007688-A1 | RADIATION CURABLE RESINS COMPRISING HYPERBRANCHED POLYESTERS | NESTE OY (FI) | 1996-03-14 | — | — | WO | disclosed |