Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1648859 | 0.78 | CYP2C19 (0.33) | LMNAALOX15CYP1B1ALDH1A1TSHR | |
| SCHEMBL8096482 | 0.75 | ALOX15 (0.39) | LMNAALOX15CYP1B1ALDH1A1 | |
| SCHEMBL11682073 | 0.70 | — | — | |
| SCHEMBL29582888 | 0.69 | LMNA (0.41) | LMNA | |
| SCHEMBL22878741 | 0.67 | — | — | |
| SCHEMBL20522668 | 0.67 | ALDH1A1 (0.39) | LMNAALOX15CYP1B1ALDH1A1TSHR | |
| SCHEMBL22528210 | 0.67 | ALDH1A1 (0.39) | LMNAALOX15CYP1B1ALDH1A1TSHR | |
| SCHEMBL2941361 | 0.67 | LMNA (0.46) | LMNAALOX15CYP1B1ALDH1A1TRPA1 | |
| SCHEMBL2697033 | 0.66 | LMNA (0.45) | LMNA | |
| SCHEMBL25217392 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8906351-B2 | 2,2′-furoin derivatives and use thereof to light skin | MERCK PATENT GMBH (DE) | 2014-12-09 | — | — | US | disclosed |
| EP-2616040-B1 | 2,2'-FUROIN DERIVATIVES AND THEIR USE FOR SKIN LIGHTENING | MERCK PATENT GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |
| EP-2616040-A1 | 2,2'-FUROIN DERIVATIVES AND USE THEREOF TO LIGHTEN SKIN | Merck Patent GmbH (DE) | 2013-07-24 | — | — | EP | disclosed |
| US-20130164230-A1 | 2,2'-FUROIN DERIVATIVES AND USE THEREOF TO LIGHT SKIN | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-06-27 | — | — | US | disclosed |
| WO-2012034629-A1 | 2,2'-FUROIN DERIVATIVES AND USE THEREOF TO LIGHTEN SKIN | MERCK PATENT GMBH (DE) | 2012-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130164230-A1 | 2,2'-FUROIN DERIVATIVES AND USE THEREOF TO LIGHT SKIN | TYR, ALDH1A2, MC1R | LMNA 1329/4885ALOX15 125/4885CYP1B1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.