Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GCGR | P47871 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974500 | 0.83 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL7977556 | 0.83 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1NPC1RAB9AMAPK1 | |
| SCHEMBL7963947 | 0.82 | RAB9A (0.70) | SMN1; SMN2ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL7977633 | 0.77 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL7977587 | 0.76 | NPC1 (0.58) | SMN1; SMN2ALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL7974288 | 0.76 | KMT2A (0.65) | SMN1; SMN2ALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL2020664 | 0.75 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1NPC1RAB9AMAPK1 | |
| SCHEMBL7964019 | 0.74 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1NPC1RAB9AMAPK1 | |
| 2-Mercaptobenzimidazole SCHEMBL7975305 | 0.73 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL7975323 | 0.72 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |