Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | CTSC | P53634 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975326 | 1.00 | CYP2D6 (0.48) | CYP2D6CCNA2CDK2CCNA1ALOX5 | |
| SCHEMBL194951 | 0.77 | CYP2D6 (0.72) | CYP2D6CCNA2CDK2CCNA1ALOX5 | |
| Water SCHEMBL3089403 | 0.76 | CYP2D6 (0.70) | CYP2D6CCNA2CDK2CCNA1ALOX5 | |
| SCHEMBL7975173 | 0.73 | CYP2D6 (0.65) | CYP2D6CCNA2CDK2CCNA1ALOX5 | |
| Fk-962 SCHEMBL239762 | 0.70 | KMT2A (0.69) | KMT2ACTSBCTSSCTSKCTSC | |
| SCHEMBL7848596 | 0.69 | POLB (0.62) | KMT2AALDH1A1POLBMEN1CA12 | |
| SCHEMBL8419841 | 0.68 | CYP2D6 (0.47) | CYP2D6ALOX5KMT2AALDH1A1HPGD | |
| Water SCHEMBL7778613 | 0.67 | CYP2D6 (0.46) | CYP2D6ALOX5KMT2AALDH1A1HPGD | |
| SCHEMBL3711592 | 0.66 | GHSR (0.58) | HPGDPOLBGHSR | |
| SCHEMBL10800533 | 0.66 | HSD11B1 (0.46) | KMT2AALDH1A1POLBCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291464-B1 | POTENTIATION OF THE CHOLINERGIC ACTIVITY; THERAPEUTIC TREATMENT OF AMNESIA, DEMENTIA OR SENILE DEMENTIA | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-09-18 | — | — | US | disclosed |
| EP-0968201-A2 | NEW AMINOPIPERAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998035951-A2 | NEW AMINOPIPERAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-08-20 | — | — | WO | disclosed |