Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 4/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CCNH | P51946 | 1/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987194 | 0.95 | HTR6 (0.37) | CYP11B1CYP11B2PDE4BPDE4DHTR6 | |
| SCHEMBL7975970 | 0.94 | HTR6 (0.39) | CYP11B1CYP11B2PDE4BPDE4DHTR6 | |
| SCHEMBL7990169 | 0.91 | PDE4B (0.37) | CYP11B1CYP11B2PDE4BPDE4DHTR6 | |
| SCHEMBL7993914 | 0.91 | HTR6 (0.38) | CYP11B1CYP11B2PDE4BPDE4DHTR6 | |
| SCHEMBL7986667 | 0.90 | CDK7 (0.44) | CYP11B1CYP11B2HTR6CCNT1CCNE1 | |
| SCHEMBL7976272 | 0.89 | CCNT1 (0.41) | CYP11B1CYP11B2HTR6CCNT1CCNE1 | |
| SCHEMBL7976003 | 0.88 | PRKCZ (0.40) | PDE4BPDE4DHTR6CDK2PRKCZ | |
| SCHEMBL7513288 | 0.88 | CDK7 (0.47) | CCNT1CCNE1CDK2CDK7CDK9 | |
| SCHEMBL7976151 | 0.88 | CCNT1 (0.37) | PDE4BPDE4DHTR6CCNT1CCNE1 | |
| SCHEMBL7987305 | 0.88 | CCNT1 (0.42) | HTR6CCNT1CCNE1CDK2CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |