Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.41 |
| ▸ | FLT1 | P17948 | 4/20 | 0.41 |
| ▸ | FLT4 | P35916 | 4/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | BLK | P51451 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CCNH | P51946 | 1/20 | 0.33 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7977291 | 0.89 | EGFR (0.38) | EGFRLCKLYNBLKKCNH2 | |
| SCHEMBL7990894 | 0.88 | EGFR (0.42) | EGFRLCKLYNBLKKCNH2 | |
| SCHEMBL7987981 | 0.87 | EGFR (0.38) | EGFRLCKLYNBLKKCNH2 | |
| SCHEMBL7990969 | 0.87 | EGFR (0.38) | EGFRLCKLYNBLKKCNH2 | |
| SCHEMBL7510914 | 0.87 | KDR (0.51) | KDRFLT1FLT4KCNH2PRKCZ | |
| SCHEMBL7976911 | 0.86 | TNF (0.36) | EGFRLCKLYNBLKKCNH2 | |
| SCHEMBL7976003 | 0.85 | PRKCZ (0.40) | KDRFLT1FLT4PRKCZCYP2A6 | |
| SCHEMBL7986901 | 0.81 | KDR (0.41) | KDRFLT1FLT4KCNH2PRKCZ | |
| SCHEMBL7548212 | 0.81 | KDR (0.39) | KDRFLT1FLT4KCNH2PRKCZ | |
| SCHEMBL7993811 | 0.80 | KDR (0.39) | KDRFLT1FLT4KCNH2PRKCZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |