Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | EED | O75530 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | ABL2 | P42684 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990448 | 0.94 | CYP11B1 (0.40) | HTR6PDE4BPDE4DCYP11B1CYP11B2 | |
| SCHEMBL7994923 | 0.93 | PRKCA (0.40) | HTR6CYP2C19CHEK1EEDPDE4B | |
| SCHEMBL7993914 | 0.93 | HTR6 (0.38) | HTR6EEDPDE4BPDE4DEGFR | |
| SCHEMBL7976272 | 0.93 | CCNT1 (0.41) | HTR6CYP2C19CHEK1EEDEGFR | |
| SCHEMBL7987194 | 0.92 | HTR6 (0.37) | HTR6CHEK1PDE4BPDE4DEGFR | |
| SCHEMBL7990463 | 0.92 | CHEK1 (0.39) | CYP2C19CHEK1EEDACP1 | |
| SCHEMBL7990169 | 0.89 | PDE4B (0.37) | HTR6PDE4BPDE4DCYP11B1CYP11B2 | |
| SCHEMBL7990984 | 0.88 | CCNT1 (0.36) | HTR6CYP2C19CHEK1EEDEGFR | |
| SCHEMBL7987981 | 0.88 | EGFR (0.38) | CYP2C19CHEK1EEDEGFRABL1 | |
| SCHEMBL7976003 | 0.87 | PRKCZ (0.40) | HTR6CHEK1PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |