Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966498 | 0.82 | HRH4 (0.40) | SMN1; SMN2NPC1RAB9AMAPTADORA3 | |
| SCHEMBL7979410 | 0.72 | DAO (0.44) | SMN1; SMN2NPC1RAB9AMAPTADORA3 | |
| SCHEMBL10140203 | 0.68 | MAT2A (0.44) | SMN1; SMN2NPC1RAB9AADORA3ADORA2A | |
| SCHEMBL10133974 | 0.68 | SIGMAR1 (0.58) | SMN1; SMN2NPC1RAB9AMAPTKDM4E | |
| SCHEMBL31577611 | 0.68 | KDM4E (0.60) | SMN1; SMN2NPC1RAB9AMAPTADORA3 | |
| SCHEMBL4640583 | 0.62 | HRH4 (0.43) | SMN1; SMN2NPC1RAB9AMAPTADORA3 | |
| SCHEMBL11043888 | 0.61 | KDM4E (0.51) | SMN1; SMN2MAPTADORA3ADORA2ACYP1A2 | |
| SCHEMBL22447052 | 0.60 | SIGMAR1 (0.52) | NPC1RAB9AMAPTHTR3AMEN1 | |
| SCHEMBL7969172 | 0.59 | NPC1 (0.53) | SMN1; SMN2NPC1RAB9AMAPTKDM4E | |
| SCHEMBL7974649 | 0.59 | MEN1 (0.47) | SMN1; SMN2NPC1RAB9AMAPTADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |