Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7977026 | 0.85 | HTR1A (0.58) | HTR1AL3MBTL1POLBSMN1; SMN2SLC6A2 | |
| SCHEMBL11767375 | 0.79 | HTR1A (0.48) | HTR1AL3MBTL1POLBSMN1; SMN2SLC6A2 | |
| SCHEMBL2599526 | 0.76 | HTR1A (0.67) | HTR1ASMN1; SMN2SLC6A2SLC6A3HTR2B | |
| Phendimetrazine SCHEMBL2325477 | 0.75 | HTR1A (0.75) | HTR1AL3MBTL1POLBSMN1; SMN2SLC6A2 | |
| Phendimetrazine SCHEMBL15064942 | 0.74 | HTR1A (1.00) | HTR1ASMN1; SMN2SLC6A2SLC6A3HTR2B | |
| Phendimetrazine SCHEMBL344020 | 0.74 | HTR1A (1.00) | HTR1ASMN1; SMN2SLC6A2SLC6A3HTR2B | |
| Phendimetrazine SCHEMBL598950 | 0.74 | HTR1A (1.00) | HTR1ASMN1; SMN2SLC6A2SLC6A3HTR2B | |
| Phendimetrazine SCHEMBL49481 | 0.74 | HTR1A (1.00) | HTR1ASMN1; SMN2SLC6A2SLC6A3HTR2B | |
| SCHEMBL4613765 | 0.73 | RIPK1 (0.48) | L3MBTL1POLBSIGMAR1RIPK1 | |
| Phendimetrazine SCHEMBL160376 | 0.72 | HTR1A (0.75) | HTR1AL3MBTL1POLBSMN1; SMN2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001007409-A1 | CARBAZOLE DERIVATIVES AND THEIR USE AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | ASTRAZENECA UK LIMITED (GB) | 2001-02-01 | — | — | WO | disclosed |