SCHEMBL7977213

SCHEMBL7977213

OC(COc1cccc2c1OCCO2)CN1CCC(c2noc3cc(F)ccc23)CC1

nearest known ligand 0.60

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 3/20 0.60
DRD2 P14416 3/20 0.60
HTR1A P08908 2/20 0.60
ACHE P22303 2/20 0.51
SLC6A4 P31645 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7975006 0.85 HTR1A (0.64) HTR2ADRD2HTR1AACHESLC6A4
SCHEMBL7975053 0.82 HTR2A (0.64) HTR2ADRD2HTR1AACHESLC6A4
SCHEMBL8158574 0.81 HTR2A (0.61) HTR2ADRD2HTR1AACHESLC6A4
Hydrochloric Acid SCHEMBL1545656 0.80 ACHE (0.69) HTR2ADRD2HTR1AACHESLC6A4
SCHEMBL7974099 0.80 HTR2A (0.68) HTR2ADRD2HTR1AACHESLC6A4
SCHEMBL7974089 0.80 HTR2A (0.68) HTR2ADRD2HTR1AACHESLC6A4
SCHEMBL1545448 0.79 HTR2A (0.77) HTR2ADRD2HTR1AACHESLC6A4
SCHEMBL1545277 0.78 HTR2A (0.61) HTR2ADRD2HTR1AACHESLC6A4
SCHEMBL1545018 0.78 DRD2 (0.72) HTR2ADRD2HTR1AACHESLC6A4
SCHEMBL8888386 0.78 DRD2 (0.61) HTR2ADRD2HTR1AACHESLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001017993-A1 ALKYLPIPERIDI NYLBENZO [D] ISOXAZOLE DERIVATIVES HAVING PSYCHOTROPIC ACTIVITY, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND A PROCESS FOR THE PREPARATION OF THE ACTIVE INGREDIENT EGIS Gyógyszergyár Rt. (HU) 2001-03-15 WO disclosed