Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | RECQL | P46063 | 3/20 | 0.39 |
| ▸ | AR | P10275 | 3/20 | 0.38 |
| ▸ | GCGR | P47871 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963868 | 0.91 | SMN1; SMN2 (0.42) | SMN1; SMN2NPC1RAB9ALMNARECQL | |
| SCHEMBL7964022 | 0.84 | AR (0.41) | SMN1; SMN2NPC1RAB9ALMNARECQL | |
| SCHEMBL7974429 | 0.84 | AR (0.42) | SMN1; SMN2NPC1RAB9ALMNARECQL | |
| SCHEMBL7974426 | 0.83 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9ALMNAAR | |
| SCHEMBL7974431 | 0.83 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9ALMNAAR | |
| SCHEMBL7974298 | 0.72 | POLB (0.50) | SMN1; SMN2NPC1RAB9ALMNARECQL | |
| SCHEMBL7963977 | 0.72 | LMNA (0.49) | SMN1; SMN2NPC1RAB9ALMNAKMT2A | |
| SCHEMBL7963998 | 0.71 | POLB (0.47) | SMN1; SMN2NPC1RAB9ALMNARECQL | |
| SCHEMBL7974453 | 0.71 | NPC1 (0.50) | SMN1; SMN2NPC1RAB9ALMNARECQL | |
| SCHEMBL7964043 | 0.70 | MAPT (0.50) | SMN1; SMN2NPC1RAB9ALMNARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |