Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974298 | 0.93 | POLB (0.50) | POLBALDH1A1HDAC1MAPTHDAC3 | |
| SCHEMBL7975380 | 0.89 | LMNA (0.47) | POLBALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL7974453 | 0.86 | NPC1 (0.50) | POLBALDH1A1HDAC1MAPTHDAC3 | |
| SCHEMBL7974397 | 0.84 | SMN1; SMN2 (0.50) | POLBALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL7977473 | 0.84 | RAB9A (0.48) | POLBALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL7964041 | 0.82 | POLB (0.47) | POLBALDH1A1HDAC1MAPTSMN1; SMN2 | |
| SCHEMBL7963992 | 0.82 | AR (0.50) | POLBALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL7980407 | 0.82 | NPC1 (0.48) | POLBALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL7964043 | 0.82 | MAPT (0.50) | POLBALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL7977623 | 0.82 | LMNA (0.55) | POLBALDH1A1MAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |