Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | MPO | P05164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7977571 | 0.87 | NPC1 (0.53) | SMN1; SMN2RAB9ANPC1MPOPOLB | |
| SCHEMBL7980389 | 0.85 | NPC1 (0.49) | RAB9ANPC1MPOPOLBLMNA | |
| SCHEMBL7977544 | 0.85 | LMNA (0.57) | SMN1; SMN2KDM4ERAB9ANPC1MPO | |
| SCHEMBL7977564 | 0.84 | POLB (0.50) | SMN1; SMN2RAB9ANPC1MPOPOLB | |
| SCHEMBL7980306 | 0.84 | NPSR1 (0.49) | RAB9ANPC1MPOPOLBGAA | |
| SCHEMBL7977587 | 0.84 | NPC1 (0.58) | SMN1; SMN2RAB9ANPC1MPOPOLB | |
| SCHEMBL7974288 | 0.84 | KMT2A (0.65) | SMN1; SMN2RAB9ANPC1MPOPOLB | |
| SCHEMBL7977633 | 0.83 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4ERAB9ANPC1MPO | |
| SCHEMBL7974434 | 0.83 | POLB (0.65) | SMN1; SMN2KDM4ERAB9ANPC1MPO | |
| SCHEMBL7980366 | 0.83 | NPSR1 (0.63) | SMN1; SMN2KDM4EPOLBLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |