Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MPO | P05164 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7977564 | 0.94 | POLB (0.50) | NPC1RAB9AKMT2ALMNASMN1; SMN2 | |
| SCHEMBL7977544 | 0.91 | LMNA (0.57) | NPC1RAB9AKMT2ALMNASMN1; SMN2 | |
| SCHEMBL7974413 | 0.87 | SMN1; SMN2 (0.59) | NPC1RAB9ALMNASMN1; SMN2MPO | |
| SCHEMBL7980366 | 0.87 | NPSR1 (0.63) | KMT2ALMNASMN1; SMN2POLBMAPK1 | |
| SCHEMBL7980318 | 0.87 | HPGD (0.51) | NPC1RAB9ALMNASMN1; SMN2MPO | |
| SCHEMBL7974436 | 0.86 | ALDH1A1 (0.61) | NPC1RAB9AKMT2ASMN1; SMN2MAPK1 | |
| SCHEMBL7980161 | 0.86 | RAB9A (0.50) | NPC1RAB9AKMT2ALMNASMN1; SMN2 | |
| SCHEMBL7974288 | 0.86 | KMT2A (0.65) | NPC1RAB9AKMT2ALMNASMN1; SMN2 | |
| SCHEMBL7980389 | 0.85 | NPC1 (0.49) | NPC1RAB9AKMT2ALMNAMPO | |
| SCHEMBL7980407 | 0.85 | NPC1 (0.48) | NPC1RAB9AKMT2ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |