Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | GAA | P10253 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982273 | 0.84 | ALDH1A1 (0.38) | ALDH1A1GAAKDM4EL3MBTL1ADORA2A | |
| SCHEMBL7979698 | 0.64 | ALDH1A1 (0.46) | ALDH1A1GAAKDM4EL3MBTL1ADORA2A | |
| SCHEMBL18430437 | 0.63 | ALDH1A1 (0.50) | ALDH1A1GAAKDM4EADORA2AHSD17B10 | |
| SCHEMBL9097378 | 0.63 | MELK (0.41) | ALDH1A1GAAKDM4EL3MBTL1ADORA2A | |
| SCHEMBL16863715 | 0.62 | ALDH1A1 (0.41) | ALDH1A1GAAKDM4EADORA2AHSD17B10 | |
| SCHEMBL14549321 | 0.62 | GPR35 (0.42) | ALDH1A1GAAKDM4EADORA2AHSD17B10 | |
| SCHEMBL3133960 | 0.62 | GAA (0.47) | ALDH1A1GAAKDM4EL3MBTL1ADORA2A | |
| SCHEMBL3135234 | 0.61 | L3MBTL1 (0.58) | ALDH1A1GAAKDM4EL3MBTL1ADORA2A | |
| SCHEMBL14954980 | 0.60 | GAA (0.55) | ALDH1A1GAAKDM4EADORA2AHSD17B10 | |
| SCHEMBL2644163 | 0.60 | APOBEC3G (0.56) | ALDH1A1GAAKDM4ESMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225310-B1 | Fused 1,2,4-thiadiazine derivatives, their preparation and use | NOVO NORDISK A/S (DK) | 2001-05-01 | — | — | US | disclosed |
| EP-1000066-A1 | FUSED 1,2,4-THIADIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999003861-A1 | FUSED 1,2,4-THIADIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1999-01-28 | — | — | WO | disclosed |