Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PTAFR | P25105 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7978633 | 0.88 | MAPT (0.41) | MAPTALOX15HSD17B10ALDH1A1KDM4E | |
| SCHEMBL7982543 | 0.83 | ALDH1A1 (0.43) | MAPTHSD17B10ALDH1A1KDM4EHPGD | |
| SCHEMBL7982544 | 0.83 | ALDH1A1 (0.43) | MAPTHSD17B10ALDH1A1KDM4EHPGD | |
| Oxalic Acid SCHEMBL7980200 | 0.81 | PTAFR (0.45) | PTAFRGRIN2BHPGDHTTGRIN1 | |
| Oxalic Acid SCHEMBL7966040 | 0.81 | PTAFR (0.45) | PTAFRGRIN2BHPGDHTTGRIN1 | |
| SCHEMBL7979963 | 0.80 | PTAFR (0.47) | PTAFRHPGDHTT | |
| SCHEMBL7979959 | 0.80 | PTAFR (0.47) | PTAFRHPGDHTT | |
| SCHEMBL7966272 | 0.80 | PTAFR (0.45) | PTAFRHPGDHTT | |
| SCHEMBL7966267 | 0.80 | PTAFR (0.45) | PTAFRHPGDHTT | |
| SCHEMBL7982982 | 0.80 | FKBP1A (0.47) | ALDH1A1MEN1KMT2ACCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |