Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | TPMT | P51580 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL535647 | 0.75 | L3MBTL1 (0.52) | KDM4EPOLBTDP1L3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7034535 | 0.73 | TDP1 (0.50) | KDM4EPOLBTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL10472839 | 0.73 | L3MBTL1 (0.50) | KDM4EPOLBTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL6271882 | 0.70 | ALDH1A1 (0.54) | KDM4ETDP1ALDH1A1LMNAGPR35 | |
| SCHEMBL7609688 | 0.69 | ALDH1A1 (0.33) | KDM4EPOLBALDH1A1MAPT | |
| SCHEMBL5154551 | 0.67 | ALDH1A1 (0.49) | KDM4EPOLBTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL22068855 | 0.66 | POLB (0.39) | KDM4EPOLBTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL5880332 | 0.66 | HSD17B10 (0.52) | KDM4EPOLBTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL3459607 | 0.66 | GPR35 (0.43) | KDM4ETDP1ALDH1A1GPR35LCK | |
| SCHEMBL27404772 | 0.66 | POLB (0.42) | KDM4EPOLBTDP1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211195-B1 | NERVOUS SYSTEM, PSYCHOLOGICAL AND GLANDULAR DISORDERS | NEUROCRINE BIOSCIENCES, INC. | 2001-04-03 | — | — | US | disclosed |
| EP-0977759-A1 | CRF ANTAGONISTIC THIOPHENOPYRIDINES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998047903-A1 | CRF ANTAGONISTIC THIOPHENOPYRIDINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-10-29 | — | — | WO | disclosed |