Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 6/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9963708 | 0.79 | BCHE (0.51) | UTS2RGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL22864178 | 0.75 | ADRB2 (0.45) | MEN1KMT2A | |
| SCHEMBL22433744 | 0.74 | ERBB2 (0.50) | MEN1KMT2AGABRA1GABRG2GABRB3 | |
| SCHEMBL26176435 | 0.72 | GPR84 (0.51) | KMT2A | |
| SCHEMBL20759412 | 0.71 | MAPT (0.45) | MEN1KMT2ATSHRHTT | |
| SCHEMBL14464030 | 0.71 | MAPT (0.45) | MEN1KMT2ATSHRHTT | |
| SCHEMBL647434 | 0.71 | AXL (0.47) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL13596793 | 0.71 | IMPDH2 (0.58) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL13596806 | 0.71 | GABRA1 (0.52) | MEN1KMT2AUTS2RGABRA1GABRG2 | |
| SCHEMBL28155368 | 0.70 | KIF11 (0.51) | MEN1KMT2AGABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147476-A1 | NOVEL PDE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-12-10 | — | — | WO | disclosed |