Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | TEAD1 | P28347 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | GPR183 | P32249 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL797736 | 0.92 | S1PR1 (0.54) | MEN1KMT2ASIGMAR1TEAD1S1PR1 | |
| SCHEMBL5791973 | 0.88 | MEN1 (0.60) | MEN1KMT2ACACNA1GDRD2HTR2A | |
| SCHEMBL797358 | 0.86 | SIGMAR1 (0.57) | CACNA1GHTR2AHTR2CSIGMAR1KCNH2 | |
| SCHEMBL797980 | 0.85 | S1PR1 (0.60) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL21820693 | 0.83 | TEAD1 (0.58) | DRD2SIGMAR1TEAD1ALDH1A1KDM4E | |
| SCHEMBL12200730 | 0.83 | L3MBTL1 (0.61) | MEN1KMT2AALDH1A1KDM4ES1PR1 | |
| SCHEMBL15942972 | 0.83 | S1PR5 (0.63) | MEN1KMT2AS1PR1S1PR4S1PR5 | |
| SCHEMBL592839 | 0.81 | MEN1 (0.66) | MEN1KMT2ASIGMAR1 | |
| SCHEMBL12412709 | 0.81 | ALDH1A1 (0.59) | MEN1KMT2ADRD2HTR2AHTR2C | |
| SCHEMBL7238102 | 0.81 | MEN1 (0.62) | MEN1KMT2ACACNA1GSIGMAR1S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8802663-B2 | Pyrazole oxadiazole derivatives as S1P1 agonists | MERCK SERONO SA (CH) | 2014-08-12 | — | — | US | disclosed |
| US-20120071460-A1 | PYRAZOLE OXADIAZOLE DERIVATIVES AS S1P1 AGONISTS | MERCK SERONO SA (CH) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071460-A1 | PYRAZOLE OXADIAZOLE DERIVATIVES AS S1P1 AGONISTS | S1PR1, S1PR3, S1PR2 | MEN1 700/4885KMT2A 3846/4885CACNA1G 996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.