Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 11/20 | 0.57 |
| ▸ | MMP9 | P14780 | 8/20 | 0.57 |
| ▸ | MMP8 | P22894 | 7/20 | 0.57 |
| ▸ | MMP1 | P03956 | 8/20 | 0.48 |
| ▸ | MMP3 | P08254 | 7/20 | 0.48 |
| ▸ | MMP7 | P09237 | 3/20 | 0.48 |
| ▸ | MMP14 | P50281 | 3/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.48 |
| ▸ | MMP20 | O60882 | 1/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.48 |
| ▸ | MMP10 | P09238 | 1/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | MMP15 | P51511 | 1/20 | 0.48 |
| ▸ | MMP16 | P51512 | 1/20 | 0.48 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 0.48 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.48 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.48 |
| ▸ | MMP24 | Q9Y5R2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13274200 | 0.90 | MMP2 (0.68) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL6838745 | 0.90 | MMP2 (0.68) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL14081288 | 0.74 | MMP2 (1.00) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL30833289 | 0.73 | MMP2 (0.44) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7983019 | 0.72 | ADAM17 (0.78) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL19286780 | 0.70 | MMP2 (0.75) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7071281 | 0.69 | LTA4H (0.50) | MMP2MMP1MMP3LTA4H | |
| SCHEMBL14081273 | 0.68 | MMP2 (0.75) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL4422008 | 0.67 | MMP2 (0.47) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL14081338 | 0.66 | MMP2 (0.71) | MMP2MMP9MMP8MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277876-B1 | Matrix metalloproteinase inhibitors | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2001-08-21 | — | — | US | disclosed |