Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 14/20 | 0.68 |
| ▸ | MMP9 | P14780 | 11/20 | 0.68 |
| ▸ | MMP8 | P22894 | 8/20 | 0.68 |
| ▸ | MMP1 | P03956 | 12/20 | 0.56 |
| ▸ | MMP14 | P50281 | 4/20 | 0.56 |
| ▸ | MMP3 | P08254 | 10/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.54 |
| ▸ | MMP7 | P09237 | 3/20 | 0.54 |
| ▸ | MMP13 | P45452 | 2/20 | 0.54 |
| ▸ | MMP20 | O60882 | 1/20 | 0.54 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.54 |
| ▸ | TNF | P01375 | 1/20 | 0.54 |
| ▸ | MMP10 | P09238 | 1/20 | 0.54 |
| ▸ | MMP12 | P39900 | 1/20 | 0.54 |
| ▸ | MMP15 | P51511 | 1/20 | 0.54 |
| ▸ | MMP16 | P51512 | 1/20 | 0.54 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 0.54 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.54 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.54 |
| ▸ | MMP24 | Q9Y5R2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13274200 | 1.00 | MMP2 (0.68) | MMP2MMP9MMP8MMP1MMP14 | |
| SCHEMBL7980261 | 0.90 | MMP2 (0.57) | MMP2MMP9MMP8MMP1MMP14 | |
| SCHEMBL30833289 | 0.83 | MMP2 (0.44) | MMP2MMP9MMP8MMP1MMP14 | |
| SCHEMBL14081288 | 0.82 | MMP2 (1.00) | MMP2MMP9MMP8MMP1MMP14 | |
| SCHEMBL14081273 | 0.78 | MMP2 (0.75) | MMP2MMP9MMP8MMP1MMP14 | |
| SCHEMBL19286780 | 0.75 | MMP2 (0.75) | MMP2MMP9MMP8MMP1MMP14 | |
| SCHEMBL19270372 | 0.73 | MMP1 (0.51) | MMP1MMP3 | |
| SCHEMBL14081338 | 0.73 | MMP2 (0.71) | MMP2MMP9MMP8MMP1MMP14 | |
| SCHEMBL25001007 | 0.73 | MMP3 (0.46) | MMP2MMP9MMP1MMP14MMP3 | |
| SCHEMBL7406329 | 0.71 | MMP1 (0.80) | MMP2MMP9MMP8MMP1MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040122011-A1 | Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy | PHARMACIA CORPORATION | 2004-06-24 | — | — | US | claimed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |
| US-20100168089-A1 | UTILIZATION OF TACE INHIBITORS FOR THE TREATMENT OF ACNE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-07-01 | — | — | US | disclosed |
| US-7413727-B2 | Contrast agents | GE HEALTHCARE AS (NO) | 2008-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122011-A1 | Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy | PTGES2, PTGS2, PTGIS | MMP2 60/4885MMP9 21/4885MMP8 20/4885 |
| US-20100168089-A1 | UTILIZATION OF TACE INHIBITORS FOR THE TREATMENT OF ACNE | MMP17, MMP25, TIMP3 | MMP2 7/4885MMP9 29/4885MMP8 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.