Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7978564 | 0.85 | MMP9 (0.43) | POLBKDM4EALDH1A1CASP1CES2 | |
| SCHEMBL7978561 | 0.85 | MMP9 (0.43) | POLBKDM4EALDH1A1CASP1CES2 | |
| SCHEMBL7251696 | 0.77 | CES2 (0.49) | L3MBTL1KDM4EALDH1A1CES2CES1 | |
| SCHEMBL14397410 | 0.77 | CES2 (0.49) | L3MBTL1KDM4EALDH1A1CES2CES1 | |
| SCHEMBL14397408 | 0.76 | ACE (0.59) | ACEPOLBTDP1L3MBTL1 | |
| SCHEMBL4573235 | 0.76 | ACE (0.61) | ACEPOLBTDP1L3MBTL1KDM4E | |
| SCHEMBL8908771 | 0.76 | ACE (0.61) | ACEPOLBTDP1L3MBTL1KDM4E | |
| SCHEMBL3840630 | 0.76 | ACE (0.61) | ACEPOLBTDP1L3MBTL1KDM4E | |
| SCHEMBL3149932 | 0.75 | ALDH1A1 (0.48) | POLBALDH1A1CES2CES1 | |
| SCHEMBL14407803 | 0.75 | ALDH1A1 (0.48) | POLBALDH1A1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6323215-B1 | TREAT AND PREVENT DISORDERS CHARACTERIZED BY NEURONAL DAMAGE SUCH AS PARKINSON'S DISEASE, ALZHEIMER'S DISEASE, STROKE, MULTIPLE SCLEROSIS, AMYOTROPHIC LATERAL SCLEROSIS, DIABETIC NEUROPATHY AND BELL'S PALSY. | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2001-11-27 | — | — | US | disclosed |