Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGAV | P06756 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7967629 | 0.91 | MAPT (0.55) | MAPTL3MBTL1LMNAKDM4EMEN1 | |
| SCHEMBL8316089 | 0.80 | MAPKAPK2 (0.55) | MAPTLMNATP53MEN1KMT2A | |
| SCHEMBL8316102 | 0.78 | MAPKAPK2 (0.55) | MAPTLMNATP53TRPM8MAPKAPK2 | |
| SCHEMBL7110432 | 0.78 | L3MBTL1 (0.60) | MAPTL3MBTL1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL7979167 | 0.77 | L3MBTL1 (0.56) | MAPTL3MBTL1LMNAKDM4EMEN1 | |
| SCHEMBL7977236 | 0.76 | L3MBTL1 (0.55) | MAPTL3MBTL1LMNAMEN1KMT2A | |
| SCHEMBL3264595 | 0.75 | KMT2A (0.57) | MAPTLMNATP53KDM4EMEN1 | |
| SCHEMBL7977557 | 0.75 | L3MBTL1 (0.47) | MAPTL3MBTL1LMNAMEN1KMT2A | |
| SCHEMBL5197720 | 0.73 | L3MBTL1 (0.59) | MAPTL3MBTL1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL3811564 | 0.73 | L3MBTL1 (0.80) | MAPTL3MBTL1LMNASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172099-B1 | CARBAZOLE, DIBENZOFURAN, OR DIBENZOTHIOPHENE DERIVATIVES; DIETETICS, ANTIDIABETIC AGENTS; ANTILIPEMICS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 2001-01-09 | — | — | US | disclosed |
| EP-0997458-A1 | NOVEL TRICYCLIC COMPOUNDS HAVING SATURATED RINGS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 2000-05-03 | — | — | EP | disclosed |