SCHEMBL7981316

SCHEMBL7981316

COc1nc(NC(C)=O)nc2ncn(CCC(COC(C)=O)COC(C)=O)c12

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.46
KDM4E B2RXH2 1/20 0.46
HPGD P15428 1/20 0.46
ADRA1A P35348 1/20 0.46
HSD17B10 Q99714 1/20 0.46
RXFP1 Q9HBX9 1/20 0.46
CYP1A2 P05177 1/20 0.34
ACHE P22303 2/20 0.34
ADORA2B P29275 1/20 0.32
DUT P33316 1/20 0.32
BCHE P06276 2/20 0.32
MEN1 O00255 1/20 0.32
TSHR P16473 1/20 0.32
KMT2A Q03164 1/20 0.32
P2RY1 P47900 2/20 0.31
PDE5A O76074 1/20 0.30
PDE3B Q13370 1/20 0.30
PDE3A Q14432 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9019784 0.76 ALDH1A1 (0.36) ALDH1A1CYP1A2ACHEBCHE
SCHEMBL3155510 0.73 KDM4E (0.58) ALDH1A1KDM4EHPGDADRA1AHSD17B10
SCHEMBL7819795 0.72 KDM4E (0.57) ALDH1A1KDM4EHPGDADRA1AHSD17B10
SCHEMBL7977956 0.70 KDM4E (0.49) ALDH1A1KDM4EHPGDADRA1AHSD17B10
SCHEMBL7981049 0.68 TLR7 (0.39) ALDH1A1KDM4EHPGDADRA1AHSD17B10
SCHEMBL3158156 0.68 KDM4E (0.69) ALDH1A1KDM4EHPGDADRA1AHSD17B10
SCHEMBL7813412 0.66 KDM4E (0.48) ALDH1A1KDM4EHPGDADRA1AHSD17B10
SCHEMBL9019826 0.65 ALDH1A1 (0.37) ALDH1A1KDM4EHPGDADRA1AHSD17B10
SCHEMBL7814812 0.65 ALDH1A1 (0.48) ALDH1A1KDM4EHPGDADRA1AHSD17B10
SCHEMBL24476593 0.65 ACHE (0.43) RXFP1ACHEBCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001094348-A1 ANTIVIRAL AGENTS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2001-12-13 WO disclosed