Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.43 |
| ▸ | PFKFB4 | Q16877 | 2/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 3/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.41 |
| ▸ | HTR6 | P50406 | 4/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | BCKDK | O14874 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6958000 | 0.85 | MAPT (0.48) | MAPTPFKFB3PFKFB4CXCR2ROCK1 | |
| SCHEMBL5845473 | 0.82 | MAPT (0.50) | MAPTPFKFB3PFKFB4CXCR2ROCK1 | |
| SCHEMBL3318210 | 0.81 | MAPT (0.49) | MAPTPFKFB3PFKFB4CXCR2ROCK1 | |
| Hydrochloric Acid SCHEMBL7984189 | 0.80 | HSD11B1 (0.54) | MAPTALDH1A1NPSR1KDM4EMCL1 | |
| SCHEMBL121489 | 0.77 | MAPT (0.50) | MAPTPFKFB3PFKFB4CXCR2ROCK1 | |
| SCHEMBL122587 | 0.77 | GPR35 (0.58) | MAPTPFKFB3PFKFB4ROCK1CMA1 | |
| SCHEMBL121696 | 0.77 | MAPT (0.50) | MAPTPFKFB3PFKFB4ROCK1ALDH1A1 | |
| SCHEMBL3133584 | 0.75 | OGG1 (0.52) | MAPTPFKFB3PFKFB4CXCR2ROCK1 | |
| SCHEMBL6950423 | 0.74 | TBXAS1 (0.56) | MAPTCXCR2ROCK1 | |
| SCHEMBL6659125 | 0.74 | MAPT (0.49) | MAPTPFKFB3PFKFB4ALDH1A1CMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001007431-A2 | BENZOTHIOPHENE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-02-01 | — | — | WO | claimed |
| WO-2001007431-A2 | BENZOTHIOPHENE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-02-01 | — | — | WO | disclosed |