Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 7/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6955656 | 0.87 | TBXAS1 (0.56) | TBXAS1PKMSMN1; SMN2TP53MAPK1 | |
| SCHEMBL1509582 | 0.84 | TBXAS1 (0.53) | TBXAS1PKMSMN1; SMN2KMT2A | |
| SCHEMBL6958000 | 0.77 | MAPT (0.48) | CXCR2ROCK1MAPT | |
| SCHEMBL6953884 | 0.76 | ADRA2C (0.45) | TBXAS1ROCK1 | |
| SCHEMBL14027515 | 0.75 | TBXAS1 (0.54) | TBXAS1 | |
| SCHEMBL5845473 | 0.74 | MAPT (0.50) | MAPK1CXCR2ROCK1MAPT | |
| SCHEMBL7981541 | 0.74 | MAPT (0.45) | CXCR2ROCK1MAPT | |
| SCHEMBL3318210 | 0.73 | MAPT (0.49) | KMT2ACXCR2ROCK1MAPT | |
| SCHEMBL10785065 | 0.73 | MAPT (0.58) | TBXAS1SMN1; SMN2MAPK1KMT2AMAPT | |
| SCHEMBL7970723 | 0.72 | ACHE (0.51) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0974584-B1 | FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-01-15 | — | — | EP | disclosed |
| US-6420375-B1 | ANTITUMOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-0974584-A1 | FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-01-26 | — | — | EP | disclosed |