Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 7/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | GNRHR | P30968 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987167 | 0.92 | KDM4E (0.45) | KDM4EPKMNAMPTTP53LMNA | |
| SCHEMBL7981945 | 0.91 | KDM4E (0.44) | KDM4EPKMNAMPTTP53LMNA | |
| SCHEMBL7989477 | 0.86 | KDM4E (0.47) | KDM4EPKMNAMPTTP53TGFBR1 | |
| SCHEMBL7989480 | 0.86 | KDM4E (0.47) | KDM4EPKMNAMPTTP53TGFBR1 | |
| SCHEMBL7983268 | 0.84 | LIMK2 (0.47) | KDM4EPKM | |
| SCHEMBL7989610 | 0.84 | ACKR3 (0.50) | TP53ACKR3LMNATGFBR1MAPT | |
| SCHEMBL7972106 | 0.84 | METTL3 (0.42) | KDM4EPKMNAMPTACKR3 | |
| SCHEMBL7983299 | 0.83 | NAMPT (0.39) | KDM4EPKMNAMPTTP53ACKR3 | |
| SCHEMBL7985797 | 0.83 | ACKR3 (0.51) | TP53ACKR3LMNAMAPT | |
| SCHEMBL7987858 | 0.81 | TGFBR1 (0.44) | KDM4EPKMTGFBR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |