Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.56 |
| ▸ | SLC22A1 | O15245 | 4/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.56 |
| ▸ | DRD3 | P35462 | 4/20 | 0.56 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.56 |
| ▸ | HRH1 | P35367 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | DRD2 | P14416 | 3/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.56 |
| ▸ | HTR2C | P28335 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980463 | 0.88 | HTR2A (0.68) | HTR2ASLC6A4SLC6A2CYP3A4SLC22A1 | |
| SCHEMBL8831796 | 0.86 | HTR2A (0.66) | HTR2ASLC6A4SLC6A2CYP3A4SLC22A1 | |
| SCHEMBL13051501 | 0.83 | HTR2A (0.78) | HTR2ASLC6A4SLC6A2CYP3A4SLC22A1 | |
| SCHEMBL11222427 | 0.79 | HTR2A (0.61) | HTR2ASLC6A4SLC6A2CYP3A4SLC22A1 | |
| SCHEMBL22018905 | 0.79 | HTR2A (0.61) | HTR2ASLC6A4SLC6A2CYP3A4SLC22A1 | |
| SCHEMBL8248673 | 0.79 | HTR2A (0.79) | HTR2ASLC6A4SLC6A2CYP3A4SLC22A1 | |
| SCHEMBL8195736 | 0.79 | HTR2A (0.61) | HTR2ASLC6A4SLC6A2CYP3A4SLC22A1 | |
| SCHEMBL6637686 | 0.79 | HTR2A (0.61) | HTR2ASLC6A4SLC6A2CYP3A4SLC22A1 | |
| SCHEMBL9404599 | 0.79 | HTR2A (0.61) | HTR2ASLC6A4SLC6A2CYP3A4SLC22A1 | |
| SCHEMBL29612136 | 0.77 | HTR7 (0.57) | DRD3DRD2HTR1ADRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235730-B1 | ANTICHOLESTEROL AGENT, ANTILIPEMIC AGENT | JAPAN TOBACCO, INC. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0970954-A1 | 3-PIPERIDYL-4-OXOQUINAZOLINE DERIVATIVES AND MEDICINCAL COMPOSITIONS CONTAINING THE SAME | JAPAN TOBACCO INC. (JP) | 2000-01-12 | — | — | EP | disclosed |