Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27692446 | 0.88 | MAPT (0.42) | SMN1; SMN2ALDH1A1KMT2AMAPTTDP1 | |
| SCHEMBL7978485 | 0.84 | SMN1; SMN2 (0.44) | KDM4ESMN1; SMN2ALDH1A1KMT2ANPC1 | |
| SCHEMBL3499943 | 0.84 | SMN1; SMN2 (0.44) | KDM4ESMN1; SMN2ALDH1A1KMT2ANPC1 | |
| SCHEMBL1653893 | 0.78 | GPR35 (0.39) | SMN1; SMN2ALDH1A1KMT2AMAPTTDP1 | |
| SCHEMBL29157410 | 0.73 | KDM4E (0.33) | KDM4ETDP1HTR2CHTR2BELANE | |
| SCHEMBL3499945 | 0.73 | CYP1A2 (0.46) | SMN1; SMN2ALDH1A1KMT2AMAPTTDP1 | |
| SCHEMBL12869701 | 0.71 | ALDH1A1 (0.45) | KDM4EALDH1A1KMT2AHTR2CHTR2B | |
| SCHEMBL28232336 | 0.69 | SLC6A3 (0.49) | SMN1; SMN2ALDH1A1KMT2ATDP1POLB | |
| SCHEMBL25343401 | 0.69 | IDO1 (0.32) | KMT2AMAPTELANE | |
| SCHEMBL11336164 | 0.68 | MAPT (0.41) | KDM4ESMN1; SMN2ALDH1A1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225306-B1 | PYRROLO(1,2A)QUINOXALINES | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 2001-05-01 | — | — | US | disclosed |