Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7094417 | 0.78 | MAPK1 (0.44) | AGTR2NR1H2NR1H3LMNAKDM4C | |
| SCHEMBL10305113 | 0.73 | NR1H2 (0.40) | AGTR2NR1H2NR1H3LMNAKDM4C | |
| SCHEMBL7992011 | 0.72 | NPC1 (0.49) | AGTR2LMNANPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8510275 | 0.71 | AGTR2 (0.33) | AGTR2KDM4C | |
| SCHEMBL12424206 | 0.70 | ALDH1A1 (0.50) | KDM4EOPRD1KCNH2MAPK1MAP3K5 | |
| SCHEMBL9369569 | 0.70 | — | — | |
| SCHEMBL5693351 | 0.70 | MAPK1 (0.43) | NR1H2NR1H3LMNAKDM4CKDM4E | |
| SCHEMBL7304678 | 0.70 | SLC6A3 (0.35) | NR1H2NR1H3LMNAKDM4CKDM4E | |
| SCHEMBL19059090 | 0.69 | MAPK1 (0.37) | AGTR2NR1H2NR1H3LMNAKDM4C | |
| SCHEMBL907962 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001066534-A2 | CYCLIC AND BICYCLIC DIAMINO HISTAMINE-3 RECEPTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 2001-09-13 | — | — | WO | disclosed |