Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 2/20 | 0.55 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.55 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.55 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ECE1 | P42892 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983086 | 1.00 | PDK1 (0.55) | PDK1PDK2PDK3PDK4MAPK14 | |
| SCHEMBL7983083 | 1.00 | PDK1 (0.55) | PDK1PDK2PDK3PDK4MAPK14 | |
| SCHEMBL29889592 | 0.79 | ABL1 (0.46) | OPRD1OPRK1BCHEECE1S1PR5 | |
| SCHEMBL107382 | 0.79 | PDK1 (0.65) | PDK1PDK2PDK3PDK4MAPK14 | |
| SCHEMBL105646 | 0.79 | PDK1 (0.65) | PDK1PDK2PDK3PDK4MAPK14 | |
| SCHEMBL13810588 | 0.79 | PDK1 (0.65) | PDK1PDK2PDK3PDK4MAPK14 | |
| SCHEMBL105647 | 0.79 | PDK1 (0.65) | PDK1PDK2PDK3PDK4MAPK14 | |
| SCHEMBL7788793 | 0.79 | GBA2 (0.51) | L3MBTL1TSHRTDP1ALDH1A1MAPK1 | |
| SCHEMBL8503604 | 0.78 | OPRD1 (0.48) | L3MBTL1TSHRTDP1ALDH1A1CYP3A4 | |
| SCHEMBL13895337 | 0.78 | PDK1 (0.55) | PDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |