Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979633 | 0.73 | ERCC5 (0.34) | MAPT | |
| SCHEMBL7980758 | 0.69 | MEN1 (0.51) | TP53MAPTGAAALDH1A1 | |
| SCHEMBL7983188 | 0.69 | ALDH1A1 (0.48) | ALDH1A1 | |
| SCHEMBL7979856 | 0.67 | HSD17B10 (0.51) | MAPTALDH1A1 | |
| SCHEMBL7982628 | 0.65 | TDP1 (0.39) | TP53MAPTALDH1A1 | |
| SCHEMBL7969549 | 0.65 | KDM4E (0.51) | TP53MAPTGAAALDH1A1 | |
| SCHEMBL7969399 | 0.64 | ALDH1A1 (0.50) | MAPTGAAALDH1A1 | |
| SCHEMBL7969572 | 0.64 | HRH4 (0.42) | MAPTALDH1A1 | |
| SCHEMBL7980201 | 0.63 | RAB9A (0.38) | TP53MAPTGAAALDH1A1 | |
| SCHEMBL7982608 | 0.62 | SMN1; SMN2 (0.45) | TP53MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174877-B1 | EXCELLANT BACTERICIDES, ORAL ABSORBABILITY AND STABILITY; IMPROVE THE STABILITY TO RENAL DEHYDROPEPTIDASE I (DHP-I); 2-(2-(N-HETEROCYCLIC-ETHYLTHIO-) DERIVATIVES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-16 | — | — | US | disclosed |
| EP-0876370-A1 | CARBAPENEM COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997025325-A1 | CARBAPENEM COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-07-17 | — | — | WO | disclosed |